"" The Dynamic Duo: Naltrexone and Bupropion – A Powerful Combination for Weight Loss - Health and Fitness Informatics


The Dynamic Duo: Naltrexone and Bupropion – A Powerful Combination for Weight Loss


Naltrexone and Bupropion

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Naltrexone and bupropion, (a combination of weight-loss medications) have been shown to be effective tools in the battle against obesity as there's no shortage of weight-loss strategies and treatments available. In this article, we'll delve into the world of Naltrexone and Bupropion for weight loss, exploring how they work, their potential benefits, and what you should know if you're considering this dynamic duo to help you on your weight loss journey.

Understanding Naltrexone and Bupropion:

Naltrexone and bupropion are two distinct medications, each with its own unique properties. However, when used together, they can complement each other's effects, resulting in a more robust approach to weight management.


Naltrexone is often prescribed to individuals struggling with addiction to opioids or alcohol. It works by blocking the effects of these substances in the brain, helping reduce dependence. Additionally, naltrexone can have an impact on eating behaviors, particularly by reducing food cravings and potentially leading to reduced calorie intake.


Bupropion, on the other hand, is primarily known as an antidepressant. It works by affecting neurotransmitters in the brain, such as dopamine and norepinephrine. These medications not only help manage symptoms of depression but also have a unique quality – they tend to be associated with weight loss rather than weight gain.

What should I tell my healthcare professional before I take this medication?

Your healthcare professional needs to know if you have any of these conditions:

  • Glaucoma
  • Heart disease
  • History of alcohol or drug abuse
  • Seizures
  • History of irregular heartbeat
  • Liver disease
  • Suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
  • Pregnant or trying to become pregnant
  • Low levels of sodium in the blood
  • Breast-feeding
  • Depression
  • Mental illness
  • Head injury
  • High blood pressure
  • History of infection or tumor of your spine or brain
  • Diabetes    
  • Eating disorders, such as bulimia or anorexia
  • History of stroke or heart attack If you often drink alcohol
  • Kidney disease
  • Taken an MAOI like Marplan, Carbex, Parnate Eldepryl, Nardil, or Parnate in the last 14 days
  • Allergic reaction to bupropion, naltrexone, other medicines, foods, dyes, or preservatives
  • Breast-feeding

How should I use this medication?

You need to take this medication orally with a glass of water, following the instructions on the prescription label. Do not crush chew, or cut, crush, the tablets; swallow them whole. You can take it with or without food, but avoid high-fat meals, as they may increase the risk of seizures. Take your medication at regular intervals and do not exceed the prescribed frequency unless advised by your doctor.

With each prescription and refill, the pharmacist will provide you with a special MedGuide. It's essential to carefully read this information every time.

If you have concerns about administering this medication to children, consult your pediatrician. They may recommend special precautions.

In case of an overdose, contact a poison control center or seek immediate medical attention.

 What if I miss a dose?

If you happen to miss a dose, simply skip it and proceed with your next scheduled dose as usual. Avoid taking additional or double doses to compensate for the missed one.

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What may interact with this medication?

You should not take this medicine with any of the following medicines:

  • Any medications used to stop taking opioids such as buprenorphine or methadone
  • Linezolid
  • MAOIs like Nardil, Marplan, Carbex, Parnate,  Eldepryl, or methylene blue (injected into a vein)
  • Often take narcotic medicines for cough or  pain
  • Other medicines that hold bupropion like Wellbutrin or Zyban

This medicine can also interact with the following medications:

  • Alcohol
  • Tamoxifen
  • Theophylline
  • Thiotepa
  • Ticlopidine
  • Tramadol
  • Warfarin
  • Certain medicines for hepatitis or HIV
  • Certain medicines for blood pressure like propranolol or metoprolol
  • Certain medicines for psychotic disturbance, depression, or anxiety
  • Certain medicines for irregular heart beat like flecainide, propafenone
  • Certain medicines for Parkinson's disease like levodopa amantadine, Certain medicines for seizures like phenytoin, carbamazepine, and Phenobarbital
  • Digoxin
  • Disulfiram
  • Furazolidone
  • Isoniazid
  • Certain medicines for sleep
  • Cimetidine
  • Clopidogrel
  • Cyclophosphamide
  • Nicotine
  • Orphenadrine
  • Procarbazine
  • Steroid medicines like cortisone or prednisone
  • Stimulant medicines to stay awake, attention disorders, weight loss

This list may not describe all possible interactions. Give your healthcare professional a list of all the herbs, medicines, dietary supplements, or non-prescription drugs you use. Also, tell them if you drink, use illegal drugs, smoke, or alcohol. Some items can interact with your medicine.

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What side effects may I notice from receiving this medication?

Side effects that you should report to your healthcare professional as soon as possible:

  • Allergic reactions like itching, skin rash, hives or itching, swelling of the face, tongue, or lips
  • Confusion
  • Fast or irregular heartbeat
  • Breathing problems
  • Changes in vision
  • Elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
  •  Increased blood pressure
  • Seizures
  • Hallucinations, loss of contact with reality
  • Fever, rash, swollen lymph nodes and fever
  • Redness, peeling, loosening of the skin, blistering, peeling, or including inside the mouth
  • Signs and symptoms of liver injury like dark brown or yellow urine; flu-like symptoms or general ill feeling; light-colored stools; nausea; loss of appetite; right upper belly pain; unusually weak or tired; yellowing of the skin or eyes
  • Suicidal thoughts or other mood changes
  • vomiting

Side effects that generally do not require medical attention:

  • Tremors
  • Constipation
  • Indigestion, stomach upset
  • Headache
  • Loss of appetite
  • Tremors

How Naltrexone and Bupropion Work Together:

When combined, naltrexone and bupropion can create a synergy that enhances their individual effects. Here's how:

1. Appetite Control: Naltrexone can help reduce cravings for high-calorie, addictive foods, while bupropion's influence on neurotransmitters can decrease overall appetite.

2. Metabolic Boost: Bupropion's impact on metabolism, leading to increased calorie burning, can complement naltrexone's appetite-reducing effects.

3. Reduced Emotional Eating: Both medications can assist in managing emotional eating patterns, promoting healthier choices.

Clinical Studies and Weight Loss Results:

Research studies have shown that this combination treatment can lead to significant weight loss. Individuals taking naltrexone and bupropion have experienced greater weight reduction compared to those using a placebo. These findings highlight the potential of this dynamic duo as a valuable tool in the fight against obesity.


Naltrexone and bupropion, when used in combination, offer a promising approach to weight management. However, it's crucial to remember that no medication is a one-size-fits-all solution. If you're considering this treatment, reach out to your healthcare provider to discuss your goals, concerns, and the most appropriate approach to help you achieve a healthier weight. With their guidance, you can explore whether the dynamic duo of naltrexone and bupropion is the right choice for your weight loss journey.


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